12TH NOVEMBER 2015 AT 4.45PM
TO BE DELIVERED BY:
PROFESSOR DAVID GRUNDY
HEAD OF DEPARTMENT OF BIOMEDICAL SCIENCES
UNIVERSITY OF SHEFFIELD
TITLE OF TALK:
WHAT HAS SENSORY NEUROBIOLOGY TOLD US ABOUT GUT DISEASE?
THE WINGATE INSTITUTE OF NEUROGASTROENTEROLOGY
26 ASHFIELD STREET
LONDON E1 2AJ
Professor David Grundy joined the Faculty of Science at the University of Sheffield in England in 1980 and is currently Head of the Department of Biomedical Science at the University. During 30 years in Sheffield he has played key roles in teaching dental, science and medical students as well as supervising more than 20 PhD students.
His research is funded from grant councils, industry and charities and focuses on the study of "Neurogastroenterology", a term which encompasses the regulation of gastrointestinal function by neural mechanisms. His interest in this field was triggered as a PhD student with Joe Davison in Dundee after completing a science degree in Physiology at Queen Elizabeth College, University of London. However, over the past 30 years the emphasis of his research has shifted from gut motor control towards the afferent mechanisms that are the basis of reflexes and gut sensations. In particular he employs neurobiological techniques to study the transduction of sensory signals generated from within the wall of the gastrointestinal tract and bladder. While the approach is largely basic science, a strong clinical element is maintained through collaborations aimed at understanding the basis of sensations such as nausea and discomfort that arise in both functional and organic GI disorders. He recently coordinated a EU Framework7 collaborative programme investigating the role of intestinal proteases in inflammatory bowel disease (IPODD) and is a member of a Marie Curie ITN dealing with training urology scientists (TRUST). The applied aspect also extends to collaborations with industry, looking at afferent transduction mechanisms as potential therapeutic targets. He spent a sabbatical in 2006 working at GSK in Harlow and from 2000 - 2005 was a guest professor at the University of Tubingen.
He is chairman of the management board of an international journal "Neurogastroenterology and Motility" and a member of the Executive Board and Senior Ethics Editor of the Journal of Physiology as well as serving on several other editorial boards and industry scientific advisory boards.
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