You are invited to participate in a research study conducted by Queen Mary University of London and King’s College London to investigate the effect of probiotics on gut health. Previous research has shown that certain probiotics may help reduce gut transit time (the time it takes for food to pass through the gut) and improve bowel habits. Hence, the use of probiotics holds promise for improving bowel function and helping to reduce symptoms of constipation.
You may be eligible if you:
• Are aged between 18 to 65 years
• Have a stool frequency (bowel movement) of 1-3 times per week
You may not be eligible if you:
• Consume many fruits and vegetables
• Regularly consume whole grain products
• Regularly take medications (e.g. laxatives), supplements or food products (e.g. fibre supplements or bran) that affect gut function
• Have any gut disease or long term health problems such as such as heart, circulation, hormonal, kidney or other chronic disease
• Are pregnant or breast-feeding
If you are interested in taking part, we will assess your eligibility and this will take place during your first appointment with us. If you are eligible and agree to take part you will need to consume a drink with or without probiotics as part of your normal diet for 4 weeks. You will also be required to provide blood samples, have your gut transit time measured by X-ray and complete questionnaires/diaries to assess your bowel habits, symptoms, diet, physical activity and psychological state. The study will take place over a ten week period, during which you will need to attend five appointments at the Clinical Research Centre in Whitechapel, where we will take a number of measurements from you including weight and height. During three of these appointments, abdominal X-rays will be taken within the Royal London Hospital, which is next to the Clinical Research Centre. All appointments should take no more than 1 hour. All information and samples that you provide will be anonymised and treated confidentially. You are under no obligation to reply to this email, however if you choose to, participation in this research is voluntary and you may withdraw at anytime.
On completion of the study, you will be compensated with £300 for your loss of earnings and travel expenses. An additional £200 (£500 overall) is available if you choose to participate in a supplementary study where we would wish you to provide stool samples. If you would like further information please email us at firstname.lastname@example.org or call 020 7882 2582.
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